Esophageal irritation/ulcers, rare ONJ (osteonecrosis of the jaw) with invasive dental procedures, rare atypical femur fractures with long-term use
Flu-like symptoms with first infusion
Low calcium levels, rare immune suppression and severe infections, rare ONJ with invasive dental procedures, rare atypical femur fractures with long-term use
Rare high calcium and kidney stones, dizziness.
In patients who have received radiation, avoid the use of these type of drugs.
Increased risks of MACE events. (MACE - Major adverse cardiac events (MACE) include heart attack; stroke, hospitalization because of heart failure; and revascularization after percutaneous coronary intervention, and coronary artery bypass graft.